Synthesis of [1-15N, 2-13C]-labeled difloxacin

B Schmidt, R Schumacher-Buffel, B Thiede…

文献索引：Schmidt, Burkhard; Schumacher-Buffel, Ramona; Thiede, Brigitte; Schaeffer, Andreas Monatshefte fur Chemie, 2009 , vol. 140, # 10 p. 1221 - 1227

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被引用次数: 2

摘要

Abstract The synthesis of [1-15 N, 2-13 C]-difloxacin, an arylfluoroquinolone antibacterial agent, is reported. As a crucial initial step, the starting materials ethyl 2, 4, 5- trifluorobenzoylacetate,[formyl-13 C]-triethyl orthoformate, and [15 N]-4-fluoroaniline were reacted to ethyl [15 N, 3-13 C]-3-(4-fluoroanilino)-2-(2, 4, 5-trifluorobenzoyl) acrylate. After cyclization and ester cleavage, the resulting intermediate was reacted with 1- ...