Tetrahedron

Ring-chain tautomerism in 2-substituted 1, 2, 3, 4-tetrahydroquinazolines A 1 H, 13 C and 15 N NMR study

J Sinkkonen, KN Zelenin, AKA Potapov, IV Lagoda…

文献索引：Sinkkonen, Jari; Zelenin, Kirill N.; Potapov, Abdul-Kadir A.; Lagoda, Igor V.; Alekseyev, Valeriy V.; Pihlaja, Kalevi Tetrahedron, 2003 , vol. 59, # 11 p. 1939 - 1950

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被引用次数: 42

摘要

In this work 32 1, 2, 3, 4-tetrahydroquinazoline derivatives were synthesized by the reaction of 2-aminomethylaniline with aldehydes and ketones and their ring-chain tautomerism studied by 1H, 13C and 15N NMR spectroscopy. The ketone, as well as the alkyl aldehyde, derivatives were found to favor exclusively ring forms, whereas tautomeric equilibria were observed for aryl aldehyde derivatives. For para-phenyl substituted compounds, good ...