Tetrahedron

A concise regioselective synthesis of hydroxyazaisoindolinones and their conversion into pyridopyridazinones

JZ Brzeziński, HB Bzowski, J Epsztajn

文献索引：Brzezinski, Jacek Z.; Bzowski, Henryk B.; Epsztajn, Jan Tetrahedron, 1996 , vol. 52, # 9 p. 3261 - 3272

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被引用次数: 19

摘要

The synthesis of pyridopyridazinones 7 and 8 via the reaction of hydroxyazaisoindolinones 5 and 6 with hydrazine hydrate is described. Compounds 7 and 8 were then subjected to reactions with alkyl halides to furnish N-alkyl derivatives. Only in the reaction of pyridopyridazinone 8 with benzyl bromide was the O-benzylpyridopyridazine 14b formed in addition to the N-benzylpyridopyridazinone 14a.