Characterization of “mini-nucleotides” as P2X receptor agonists in rat cardiomyocyte cultures. An integrated synthetic, biochemical, and theoretical study

…, I Rutman-Halili, V Shneyvays, T Zinman…

文献索引：Fischer, Bilha; Yefidoff, Revital; Major, Dan T.; Rutman-Halili, Irit; Shneyvays, Valadimir; Zinman, Tova; Jacobson, Kenneth A.; Shainberg, Asher Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2685 - 2696

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被引用次数: 26

摘要

The design and synthesis of “mini-nucleotides”, based on a xanthine-alkyl phosphate scaffold, are described. The physiological effects of the new compounds were evaluated in rat cardiac cell culture regarding Ca2+ elevation and contractility. The results indicate biochemical and physiological profiles similar to those of ATP, although at higher concentrations. The biological target molecules of these “mini-nucleotides” were identified ...