5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfon-amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor …
…, DN Middlemiss, SF Moss, H Newman…
文献索引：Bromidge, Steven M.; Brown, Anthony M.; Clarke, Stephen E.; Dodgson, Kathy; Gager, Tracey; Grassam, Helen L.; Jeffrey, Phil M.; Joiner, Graham F.; King, Frank D.; Middlemiss, Derek N.; Moss, Stephen F.; Newman, Helen; Riley, Graham; Routledge, Carol; Wyman, Paul Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 202 - 205
The 5-hydroxytryptamine (5-HT, serotonin) superfamily of receptors currently consists of 7 classes (5-HT1-5-HT7) that embrace 14 human subclasses. 1 The most recent addition is the 5-HT6 receptor which was first cloned from rat striatal mRNA in 1993 by two independent groups. 2 The human 5-HT6 receptor, cloned in 1994 by Kohen et al., 3 is a 440-amino acid polypeptide with seven transmembrane spanning domains typical of G-protein-coupled ...
