Tetrahedron letters

An intramolecular palladium-catalysed aryl amination reaction to produce benzimidazoles

CT Brain, SA Brunton

文献索引：Brain, Christopher T; Brunton, Shirley A Tetrahedron Letters, 2002 , vol. 43, # 10 p. 1893 - 1895

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被引用次数: 159

摘要

The benzimidazole nucleus is of significant importance to medicinal chemistry. Recent publications have reported benzimidazole-containing compounds showing biological activity as selective neuropeptide Y Y1 receptor antagonists, 1 5-lipoxygenase inhibitors for use as novel antiallergic agents, 2 factor Xa (FXa) inhibitors, 3 poly(ADP-ribose)polymerase (PARP) inhibitors 4 and as human cytomegalovirus (HCMV) inhibitors. 5 The traditional synthesis of benzimidazoles ...