Synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors of steroid-5α-reductase type 1 and 2

…, E Baston, W Reichert, RW Hartmann

文献索引：Picard, Franck; Baston, Eckhard; Reichert, Wolfgang; Hartmann, Rolf W. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 6 p. 1479 - 1487

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被引用次数: 50

摘要

The synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) is described [benzoyl (1), benzyl (2), adamantanoyl (3), cyclohexanoyl (4), cyclohexylacetyl (5), diphenylacetyl (6), dicyclohexylacetyl (7), 2-propylpentanoyl (8), diphenylcarbamoyl (9), trimethylacetyl (10), 3, 3-dimethylacryloyl (11), dicyclohexylacetyl derivative of the benzyl compound (12)]. Compounds were tested for inhibitory activity toward 5α-reductase ...