Total Synthesis of (+/−)??Frondosin B and (+/−)??5??epi??Liphagal by Using a Concise (4+ 3) Cycloaddition Approach

…, B Verbraeken, K Van Hecke…

文献索引：Laplace, Duchan R.; Verbraeken, Bart; Van Hecke, Kristof; Winne, Johan M. Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 253 - 262

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被引用次数: 16

摘要

Abstract A recently developed (4+ 3) cycloaddition between dienes and furfuryl alcohols, as precursors of oxyallyl-type cations, has been used as a key step in the racemic syntheses of two natural products: frondosin B and liphagal. This work demonstrates the synthetic potential of this cycloaddition reaction, and offers a short synthetic route to an interesting family of natural products. A full account of these synthetic studies is presented, further ...