Abstract A divergent synthesis of substituted benzo [c][2, 7] naphthyridines 5a-h is described, which features an intramolecular pyridyne cyclization step as the key reaction. The pyridyne precursors are conveniently prepared from the pyridinium hydrochloride 2 and the requisite anilines. Cyclization of the non-symmetric substrates 3e and 3f did not proceed with significant regioselectivity.
![7-methylbenzo[c][2,7]naphthyridine结构式](https://image.chemsrc.com/caspic/001/143770-47-2.png)
