The stereocontrolled synthesis of the sodium salt of NodRmlv (S), the bacterial chemical signal involved in the Rhizobium meliloti-alfalfa symbiosis, has been achieved in an overall yield of 8%. ... The initial stages of the symbiotic relationship between Rhizobiurn bacteria and leguminous plants are established by an exchange of chemical signals.1 Flavonoids produced by the host plant induce, in the bacterium, the production of specific signal molecules (Nod factors) ...