Tetrahedron

Synthesis and applications of a new base-labile fluorene derived linker for solid-phase peptide synthesis

F Rabanal, E Giralt, F Albericio

文献索引：Rabanal, Francesc; Giralt, Ernest; Albericio, Fernando Tetrahedron, 1995 , vol. 51, # 5 p. 1449 - 1458

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被引用次数: 43

摘要

The handle N-[(9-hydroxymethyl)-2-fluorenyl] succinamic acid (HMFS) is reported for the preparation of protected peptide segments in combination with a Boc/Bzl protection scheme. Treatment of peptide-resins with morpholine in DMF renders protected peptides in high yields and purities.