Stereoselective, Dual-Mode Ruthenium-Catalyzed Ring Expansion of Alkynylcyclopropanols

BM Trost, J Xie, N Maulide

文献索引：Trost, Barry M.; Xie, Jia; Maulide, Nuno Journal of the American Chemical Society, 2008 , vol. 130, # 51 p. 17258 - 17259

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被引用次数: 55

摘要

A novel, dual-pathway ring expansion of alkynylcyclopropanols is described. On treatment with a ruthenium catalyst, these compounds undergo highly selective enlargement to either (Z)-alkylidene cyclobutanones or β-substituted cyclopentenones. The unique ability to access the least selective double bond isomers of alkylidene cyclobutanones and the dramatic shift of reactivity observed further illustrate the particular intricacies of ruthenium ...