An R??Selective Hydroxynitrile Lyase from Arabidopsis thaliana with an α/β??Hydrolase Fold

J Andexer, J von Langermann, A Mell…

文献索引：Andexer, Jennifer; Von Langermann, Jan; Mell, Annett; Bocola, Marco; Kragl, Udo; Eggert, Thorsten; Pohl, Martina Angewandte Chemie - International Edition, 2007 , vol. 46, # 45 p. 8679 - 8681

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被引用次数: 61

摘要

Hydroxynitrile lyases (HNLs) catalyze the stereoselective formation of CÀC bonds between HCN and aldehydes or ketones yielding chiral cyanohydrins, which are versatile building blocks for the pharmaceutical and agrochemical industries.[1] Among the most important cyanohdrins are chiral a-hydroxy acids such as substituted mandelic acids,[1e, f, 2a] m- phenoxybenzaldehyde derivatives,[2c] and structures with additional aliphatic linkers ...