1, 5-Benzodiazepines IX. A new route to substituted 4H-[1, 2, 4] triazolo [4, 3-a][1, 5] benzodiazepin-5-amines with analgesic and/or anti-inflammatory activities

…, GC Grossi, M Di Braccio, M Ghia, F Mattioli

文献索引：Roma; Grossi; Di Braccio; Ghia; Mattioli European Journal of Medicinal Chemistry, 1991 , vol. 26, # 5 p. 489 - 496

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被引用次数: 45

摘要

Abstract A new two-step synthetic pathway to substituted 4H-[1, 2, 4] triazolo [4, 3-a][1, 5] benzodiazepin-5-amines 2a–p is described. The cyclocondensation of (dimethylamino) benzodiazepinone 1a with hydrazides afforded triazolobenzodiazepinones 5 which in turn reacted with suitable primary or secondary amines, in the presence of titanium tetrachloride, to give the desired 5-amino-derivatives 2a–p. When compounds 5 were treated with the ...