A novel imidazole nucleoside containing a diaminodihydro-S-triazine as a substituent: inhibitory activity against the West Nile virus NTPase/helicase

…, R Schuessler, P Borowski, K Kalicharran…

文献索引：Ujjinamatada, Ravi K.; Agasimundin, Yankanagouda S.; Zhang, Peng; Hosmane, Ramachandra S.; Schuessler, Roman; Borowski, Peter; Kalicharran, Kishna; Fattom, Ali Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 10-12 p. 1775 - 1788

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被引用次数: 4

摘要

The attempted synthesis of a ring-expanded guanosine (1) containing the imidazo [4, 5-e][1, 3] diazepine ring system by condensation of 1-(2′-deoxy-β-D-erythropentofuranosyl)-4- ethoxycarbonylimidazole-5-carbaldehyde (2) with guanidine resulted in the formation of an unexpected product, 1-(2′-deoxy-β-D-erythropentofuranosyl)-5-(2, 4-diamino-3, 6-dihydro- 1, 3, 5-triazin-6-yl) imidazole-4-carboxamide (7). The structure as well as the pathway of ...