Tetrahedron letters

Synthesis of pyrrolidin-1-yl analogues of pyrimidine dideoxynucleosides

MR Harnden, RL Jarvest

文献索引：Harnden, Michael R.; Jarvest, Richard L. Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3863 - 3866

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被引用次数: 29

摘要

Abstract The synthesis is described of the first members of a new class of nucleoside analogues in which the tetrahydrofuran ring is replaced by a pyrrolidine ring linked to the base through an NN bond: the pyrrolidinyl analogues of 2′, 3′-dideoxycytidine (10), uridine (8), and thymidine (9) were prepared via construction of the base on a 1- aminopyrrolidine (15).