Synthesis and psychotropic properties of 4-amino-3-cyano-1, 2-dihydrospiro (naphthalene-2, 1'cyclopentane) derivatives

AI Markosyan, MG Oganisyan, RA Kuroyan…

文献索引：Markosyan, A. I.; Oganisyan, M. G.; Kuroyan, R. A.; Sukasyan, R. S.; Arzanunts, E. M.; Sarkisyan, I S. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 8 p. 536 - 539 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 8 p. 26 - 28

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被引用次数: 12

摘要

By condensation of aminonitrile II with benzaldehyde and orthoformic ester, the Schiff base III and the ethoxymethylene compound IV were obtained. Bromination of aminonitrile II in glacial acetic acid and subsequent treatment with a base gave 3-bromo-4-oxo-3-cyano-1, 2, 3, 4-tetrahydrospiro (naphthalene-2, 1'-cyclopentane)(V). the reaction of aminonitrile II with carboxylic acid chlorides was studied and the following patterns were discovered. The ...