Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives

XC Huang, M Wang, YM Pan, XY Tian, HS Wang…

文献索引：Huang, Xiao-Chao; Wang, Meng; Pan, Ying-Ming; Tian, Xiao-Yan; Wang, Heng-Shan; Zhang, Ye Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5283 - 5289

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被引用次数: 22

摘要

Abstract A series of novel α-aminophosphonate derivatives containing DHA structure were designed and synthesized as antitumor agents. In vitro antitumor activities of these compounds against the NCI-H460 (human lung cancer cell), A549 (human lung adenocarcinoma cell), HepG2 (human liver cancer cell) and SKOV3 (human ovarian cancer cell) human cancer cell lines were evaluated and compared with commercial anticancer ...