1-Oxa-3, 8-diazaspiro [4.5] decan-2-one derivatives with a potent inhibitory effect on neural Ca-uptake and protecting action against TET-induced brain edema and …

…, E Palosi, A Kis-Varga, M Paroczai, S Szabo…

文献索引：Toth; Kiss; Gere; Karpati; Toerley; Palosi; Kis-Varga; Paroczai; Szabo; Groo; Laszlovszky; Lapis; Csomor; Szporny European Journal of Medicinal Chemistry, 1997 , vol. 32, # 1 p. 27 - 38

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被引用次数: 9

摘要

A series of novel 1-oxa-3, 8-diazaspiro [4.5] decan-2-one derivatives 8–71 were synthesized. Several representatives were examined for their in vitro inhibitory action on 45Ca-uptake into cerebrocortical synaptosomes depolarized by potassium and veratrine and on triethyltin-induced brain edema. Of the compounds displaying most potent inhibitory action on veratrine-induced 45Ca-uptake into cerebrocortical synaptosomes and ...