European journal of medicinal chemistry

Synthesis and preliminary data on the biocompatibility and emulsifying properties of perfluoroalkylated phosphoramidates as injectable surfactants

MP Krafft, P Vierling, JG Riess

文献索引：Krafft; Vierling; Riess European Journal of Medicinal Chemistry, 1991 , vol. 26, # 5 p. 545 - 550

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被引用次数: 20

摘要

Abstract Perfluoroalkylated dimorpholinophosphoramidates, 1–4, were synthesized in 65– 80% yield by phosphorylation of the appropriate perfluoroalkylated alcohol by phosphorus oxytrichloride, followed by reaction with morpholine. Preliminary biological tests (effect on cell cultures, hemolysis of red blood cells, and acute in vivo toxicity in mice) performed on compounds 1 to 5 show that the F-alkylated derivatives 1 to 4 are better tolerated than ...