Coibacins A and B: Total synthesis and stereochemical revision

VMT Carneiro, CM Avila, MJ Balunas…

文献索引：Carneiro, Vania M. T.; Avila, Carolina M.; Balunas, Marcy J.; Gerwick, William H.; Pilli, Ronaldo A. Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 630 - 642

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被引用次数: 9

摘要

The interface between synthetic organic chemistry and natural products was explored in order to unravel the structure of coibacin A, a metabolite isolated from the marine cyanobacterium cf. Oscillatoria sp. that exhibits selective antileishmanial activity and potent anti-inflammatory properties. Our synthetic plan focused on a convergent strategy that allows rapid access to the desired target by coupling of three key fragments involving E-selective ...