Molecules

Synthesis of precursors for the oxidative tandem cyclization of diphenols to galanthamine analogs

M Treu, U Jordis

文献索引：Treu, Matthias; Jordis, Ulrich Molecules, 2002 , vol. 7, # 1 p. 18 - 25

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被引用次数: 4

摘要

Galanthamine is an alkaloidal acetylcholinesterase inhibitor (AChEI) which has been approved in several countries for treating symptoms of Alzheimer's type senile dementia [1,2]. In the course of our investigations into the oxidative tandem cyclization protocol [3,4,5,6,7,8] we sought to extend this reaction type to the preparation of carbocyclic galanthamine analogs. To study this approach, we needed 4-bromo-5-[2-(4-hydroxybenzyl)benzyl]-2-methoxyphenol (9) and ...