Abstract: A new and rapid synthesis of (S)-3-aminopyrrolidines z is proposed from N- protected (S)-Asparagine. Basic cyclization of methyl NZ-(S)-Asparaginate 1 followed by onepot N-benzylation directly leads to (S)-aminosuccinimide 3 which, after cleavage of the Z- protecting group, is converted to corresponding imines and readily reduced to disubstitut~ chiral 3-aminopy~ olidines 2. Almost no ra~ emization (~ 5%) of the original amino-acid as ...
