Generation and Reactions of Heteroaromatic Lithium Compounds by Using In-Line Mixer in a Continuous Flow Microreactor System at Mild Conditions

B Liu, Y Fan, X Lv, X Liu, Y Yang…

文献索引：Liu, Binjie; Fan, Yong; Lv, Xiaoming; Liu, Xiaofeng; Yang, Yongtai; Jia, Yu Organic Process Research and Development, 2013 , vol. 17, # 1 p. 133 - 137

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被引用次数: 10

摘要

A lithium–halogen exchange reaction procedure was applied to introduce electrophilic substituents to the heteroaromatics, which exhibited potential in the syntheses of pharmaceutical intermediates. In this contribution, generation and reactions of heteroaromatic lithium compounds were successfully accomplished at 10° C in a continuous flow microreactor equipped with an in-line mixer. Extensive reaction results revealed that ...