Synthesis and analgesic activity of 4-anilides of 1-substituted-2, 5-dimethylpiperidines

RS Vartanyan, VO Martirosyan, SA Vartanyan…

文献索引：Vartanyan, R.S.; Martirosyan, V.O.; Vartanyan, S.A.; Vlasenko, E.V.; Durgaryan, L.K.; Azlivyan, A.S. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 5 p. 383 - 387 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 5 p. 562 - 565

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被引用次数: 2

摘要

The 4-anilinopiperidines are currently the strongest class of analgesics used in medical practice. The atoms and groups responsible for the analgesic activity are those capable of donor-acceptor interactions with an appropriate receptor system. However, it is well known that activity of these compounds can be significantly affected when groups and atoms are introduced that are not capable of such interactions. For example, the analgesic action of ...