Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3 (2H)-furanones

…, I Jirkovsky, KA Memoli, L Borella, C Wells…

文献索引：Felman; Jirkovsky; Memoli; Borella; Wells; Russell; Ward Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1183 - 1190

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被引用次数: 33

摘要

In order to investigate new antiulcer agents, spizofurone 1 (AG-629) was fragmented and reassembled to generate 5-phenyl-2, 2-dimethy1-3 (2H)-furanone (bullatenone, 2). Because of the antiulcer activity of 2, 5-phenyl-substituted 2, 2-dimethyl-3 (2H)-furanones (3-6) were made and shown to have poor activity. Insertion of an ethenyl link between the furanone and phenyl rings gave 5-(2-phenylethenyl)-2, 2-dimethyl-3 (2H)-furanone (7). This compound ...