Synlett

The use of calcium carbide in the synthesis of 1-monosubstituted aryl 1, 2, 3-triazole via click chemistry

Y Jiang, C Kuang, Q Yang

文献索引：Jiang, Yubo; Kuang, Chunxiang; Yang, Qing Synlett, 2009 , # 19 p. 3163 - 3166

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被引用次数: 42

摘要

Abstract The synthesis of 1-monosubstituted aryl 1, 2, 3-triazoles was achieved using calcium carbide as a source of acetylene. The copper-catalyzed 1, 3-dipolar cycloaddition reactions were carried out without nitrogen protection and in a MeCN-H 2 O mixture. The yields ranged from moderate to excellent. The reaction conditions were found to be successful for aryl azide reactants, including analogues with various functionalities.