Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (ADEPT): a phenol nitrogen mustard carbamate

F Schmidt, JC Florent, C Monneret, R Straub…

文献索引：Schmidt; Florent; Monneret; Straub; Czech; Gerken; Bosslet Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 8 p. 1071 - 1076

全文：HTML全文

被引用次数: 37

摘要

A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-(ortho- hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed low cytotoxicity, it must be considered as appropriate for an ADEPT approach.