Tetrahedron Letters

Regioselective lactonization of naphthoquinones: synthesis and antitumoral activity of the WS-5995 antibiotics

G Qabaja, EM Perchellet, JP Perchellet, GB Jones

文献索引：Qabaja, Ghassan; M. Perchellet, Elisabeth; Perchellet, Jean-Pierre; Jones, Graham B. Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3007 - 3010

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被引用次数: 20

摘要

An acid promoted quinolactonization of naphthoquinones has been developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C and functional analogs is demonstrated. Preliminary antitumoral activity of the analogs is presented together with electrochemical analysis.