N-Heterocyclic compounds as radioprotectors II. Derivatives of pyridine and pyrimidine containing thiol precursors

JH Barnes, M Fatome, CEL Jones, SG Murray

文献索引：Barnes, John H.; Fatome, Marc; Jones, Christopher E. L.; Murray, Stephen G. European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 211 - 216

全文：HTML全文

被引用次数: 3

摘要

Abstract Pyridine and 4-substituted pyrimidine derivatives incorporating a sulphur functional side-group were evaluated as potential radioprotective agents by screening tests in mice. 2- (2-Pyridyl) ethanethiol and its derivatives showed some radioprotective action when administered intraperitoneally, but all were inferior to 2-pyridinemethanethiol. They showed no protection when administered orally. Substitution of the pyridine ring by chlorine gave ...