Chemical synthesis, biological evaluation and structure–activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as …

…, P Constant, A Quémard, V Bernardes-Génisson…

文献索引：Deraeve, Celine; Dorobantu, Ioana Miruna; Rebbah, Farah; Le Quemener, Frederic; Constant, Patricia; Quemard, Annaik; Bernardes-Genisson, Vania; Bernadou, Jean; Pratviel, Genevieve Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6225 - 6232

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被引用次数: 10

摘要

The synthesis and biological evaluation of azaisoindolinone compounds embedding a lipophilic chain on the framework were performed. These compounds were designed as InhA inhibitors and as anti-Mycobacterium tuberculosis agents. Structure–activity relationships concerning the length and the location of the lipophilic chain around the azaisoindolinone framework, the suppression of the phenyl group, the bioisosteric ...