Tetrahedron letters

Synthesis of 9-(3-hydroxypropoxy) guanine, a novel antiviral acyclonucleoside

MR Harnden, A Parkin, PG Wyatt

文献索引：Harnden, M. R.; Parkin, A.; Wyatt, P. G. Tetrahedron Letters, 1988 , vol. 29, # 6 p. 701 - 704

全文：HTML全文

被引用次数: 26

摘要

ABSTRACT: Synthetic approaches to 9-(3-hydroxypropoxy) guanine (2) involving the intermediacy of either a 1-alkoxyimidazole (1) or a 4-alkoxyaminopyrimidine (13) are described. This 9-alkoxyguanine (L) has potent and selective anti-herpesvirus activityand is the first reported member of a new series of antiviral acyclonucleosides.