Benzylpiperazine derivatives. II. Syntheses and cerebral vasodilating activities of 1-((3-alkyl-3-hydroxy-3-phenyl) propyl)-4-benzylpiperazine derivatives.

…, Y FUJIMOTO, K YOSHIDA, T KANAZAWA…

文献索引：Ohtaka; Fujimoto; Yoshida; Kanazawa; Ito; Tsukamoto Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 7 p. 2782 - 2791

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被引用次数: 7

摘要

Analogs of 1-[(3-alkyl-3-hydroxy-3-phenyl) propyl]-4-(2, 3, 4-trimethoxybenzyl) piperazine (1) were prepared and tested for cerebral vasodilating activity. It was found that the potency depends positively on the number of methoxyl groups on the benzyl moiety, and the homopiperazine analogs seem to be equipotent to the corresponding piperazines. From the standpoints of potency and ease of synthesis, 8k was selected for further study. Further ...