Synthetic communications

A new simple route to N-substituted 2-aminoethylphosphonic acids

X Fu, C Gong, X Ma, S Wen

文献索引：Fu, Xiangkai; Gong, Chengbin; Ma, Xuebing; Wen, Shuying Synthetic Communications, 1998 , vol. 28, # 14 p. 2659 - 2664

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被引用次数: 24

摘要

Abstract 2-Aminoethylphosphonic acid (AEPA) and its N-substituted compounds were prepared by one step reaction using 2-chloroethylphosphonic acid with ammonia and amines (H2NMe, HNMeMe, HNEtEt, H2NPr-n, H2NCH2ph, H2NCH2CH2NH2 and H2N (C= NH) NH2 in a dilute alkaline solution below 20° C with simple work-up and easy purification. The reaction was accelerated by catalytic amount of potassium iodide. The yield for the ...