Synthesis and pharmacological activity of analogs of the hypotensive drug Foridon

…, GY Dubur, IP Skrastin'sh, AA Kimenis

文献索引：Kastron, V. V.; Vitolin', R. O.; Dubur, G. Ya.; Skrastin'sh, I. P.; Kimenis, A. A. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 5 p. 327 - 331 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 5 p. 554 - 559

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摘要

The following Foridon analogs were synthesized: 3, 5-dicarboxylates of 1, 4- dihydropyridines with a longer alkyl chain (Ib, c) and the monoanilide of 1, 4-dihydropyridine 3, 5-dicarboxylate (id). In addition, we synthesized three compounds (le-g) in which the oxygen atom in the OCHFa group was replaced by a~ dlfur atom.