Synthesis and Biological Evaluation of Novel Phosphonates Derivatives of As Potential Antitumor Agents

C Jin, YJ Liang, H He, L Fu

文献索引：Jin, Chuanfei; Liang, Yong-Ju; He, Hongwu; Fu, Liwu Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 10 p. 2096 - 2103

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被引用次数: 6

摘要

Abstract A series of dialkyl [2-(4, 6-dimethoxypyrimidin-2-yloxy) benzamido](aryl) methylphosphonates derivatives were designed and synthesized. All the new compounds were identified by elemental analysis, IR, 1H NMR, 31P NMR, and MS. Their antitumor activity against KB and CNE1 cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further study of structure ...