Tetrahedron

Synthesis of sulfur-substituted quinolizidines and pyrido [1, 2-a] azepines by ring-closing metathesis

SSP Chou, CF Liang, TM Lee, CF Liu

文献索引：Chou, Shang-Shing P.; Liang, Chu-Fang; Lee, Tse-Ming; Liu, Chih-Fen Tetrahedron, 2007 , vol. 63, # 34 p. 8267 - 8273

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被引用次数: 25

摘要

Sulfur-substituted quinolizidines and pyrido [1, 2-a] azepines (7) can be prepared by ring- closing metathesis (RCM) of 4-(phenylthio)-1, 2, 5, 6-tetrahydropyridin-2-ones (6) bearing terminal alkenyl groups at both N-1 and C-6 positions, which are obtained from 3- (phenylthio)-3-sulfolene (1) in four steps. Some synthetic transformations of 2-(phenylthio)-1, 6, 9, 9a-tetrahydroquinolizin-4-one (7a) and 2-(phenylthio)-1, 6, 9, 10, 10a- ...