Despite the progress, the state-of-the-art for acyl oxazole synthesis remains less than ideal. Charged with providing multigram quantities of a potential new drug candidate bearing this structural motif, we became interested in developing a new approach to 2-acyl oxazoles. Because of the reported instability of 2-lithio oxazoles in THF at temperatures above −40 °C, 10 our first priority was to determine an alternative metal counterion. On the basis of recently reported ...
