Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlations

MC Wani, AW Nicholas, G Manikumar…

文献索引：Wani; Nicholas; Manikumar; Wall Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1774 - 1779

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被引用次数: 145

摘要

Nineteen racemic ring A substituted analogues of the antitumor agent 2O (S)-camptothecin were prepared by total synthesis and evaluated for in vitro cytotoxic activity against KB cell culture and in vivo antileukemic activity against L1210. These compounds bore a wide variety of substitutents at Cl1 designed to confer upon the ring system a broad range of combinations of electronic, steric, and lipophilic effects. A few Clo-substituted derivatives ...