An efficient, one-pot synthesis of various ceramide 1-phosphates from sphingosine 1-phosphate

P Nussbaumer, V Hornillos, M Ghobrial…

文献索引：Nussbaumer, Peter; Hornillos, Valentin; Ghobrial, Michael; Ullrich, Thomas Chemistry and Physics of Lipids, 2008 , vol. 151, # 2 p. 125 - 128

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被引用次数: 3

摘要

An efficient, one-pot procedure for the synthesis of ceramide 1-phosphates with varying N- acyl substituents, to serve as tool compounds for analytical and biological investigations, was developed. Sphingosine 1-phosphate was silylated in situ to increase its solubility and to protect the 3-hydroxy functionality and then allowed to react with activated acid derivatives in the presence of diisopropylethylamine. Simultaneous cleavage of the silyl protecting ...