Bioorganic & medicinal chemistry

The anticonvulsant activities of N-benzyl 3-methoxypropionamides

SV Andurkar, JP Stables, H Kohn

文献索引：Andurkar, Shridhar V.; Stables, James P.; Kohn, Harold Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2381 - 2389

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被引用次数: 38

摘要

We recently reported that the ED50 value for (R, S)-2, 3-dimethoxypropionamide (1) in the maximal electroshock (MES)-induced seizure test in mice was 30 mg/kg (Choi, D.; Stables, JP, Kohn, H. Bioorg. Med. Chem. 1996, 4, 2105). This value is comparable to that observed for phenobarbital (ED50= 22 mg/kg). Compound 1 is structurally similar to a class of MES- selective anticonvulsant agents, termed functionalized amino acids (2), that were ...