Synthesis of some N??[pyridyl (phenyl) carbonylamino] hydroxyalkyl??(benzyl)??1, 2, 3, 6??tetrahydropyridines as potential anti??inflammatory agents

…, KK Redda, FY Onayemi, H Melles…

文献索引：Rao; Redda; Onayemi; Melles; Choi Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 307 - 315

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被引用次数: 15

摘要

Abstract 1, 2, 3, 6-Tetrahydropyridines are known to possess analgesic, anti-inflammatory, hyperglycemic and hypoglycemic activities. Substituted 2, 4-dinitrophenylpyridinium chlorides 3 were formed by reacting 1-chloro-2, 4-dinitrobenzene with hydroxypropyl, hydroxymethyl and benzyl substituted pyridines 2. Attack of the pyridinium chlorides 3 with pyridylcarbonyl hydrazides or benzoyl hydrazides 4 gave the isolable 2, 4-dinitroanilino ...