Studies on Carcinostatic Substances. XXXIV. Anti-tumor Activity of 2, 2-Bis (2-chloroethyl) isoxazolidinium Chloride and Related Compounds.

M Ishidate, Y Sakurai, M Torigoe

文献索引：Ishidate,M. et al. Chemical and Pharmaceutical Bulletin, 1961 , vol. 9, p. 485 - 491

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被引用次数: 5

摘要

In the course of investigation of N-oxides of nitrogen mustard, 2, 2-bis (2-chloroethyl)- isoxazolidinium chloride was expectedly obtained by oxidation of N, N-bis (2-chloroethyl)-3- chloropropylamine with peracid. This compound drew interest of the present authors because it was found to be readily reduced by catalytic reduction to 3-bis (2-chloroethyl)- amino-1-propanol, which is one of the active bifunctional alkylating agents. As 2- ...