Organocatalytic Asymmetric Synthesis of Versatile γ??Lactams

TB Poulsen, G Dickmeiss, J Overgaard…

文献索引：Poulsen, Thomas B.; Dickmeiss, Gustav; Overgaard, Jacob; Jorgensen, Karl Anker Angewandte Chemie - International Edition, 2008 , vol. 47, # 25 p. 4687 - 4690

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被引用次数: 28

摘要

Molecules of natural origin containing a functionalized glactam (pyrrolidin-2-one) ring system with a quaternary stereocenter [1] at C5 hold a prominent position in chemistry and biology. Important examples of these g-lactams include the proteasome inhibitors lactacystin and salinosporamide A, dysibetaine, and several examples from the oxazolomycin family of antibiotics (Scheme 1). The biological profiles of these molecules, combined with the ...