Synthesis and antiarrhythmic activity of epimeric 17-amino-5α-androstan-3-ols and their derivatives

…, VI Sladkov, EV Dorodnikova, MD Mashkovskii…

文献索引：Nadaraia, N. Sh.; Sladkov, V. I.; Dorodnikova, E. V.; Mashkovskii, M. D.; Kemertelidze, E. P.; Suvorov, N. N. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 3 p. 207 - 212 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 3 p. 288 - 293

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摘要

The structures of the isomeric 17-amino-Sa-androstan-3-ols (I-IV), and those of their derivatives (V-XII, XIV, XVl, XVIII, XX, XXII, XXIV, andXXVII-XXX) were in good agreement with their elemental analyses, IR and mass spectra (Table i). The elemental analyses, yields, and melting points of the hydrochlorides (la-IVa, Vlla-IXa, Xla, XIVa, XVIa, XVIIIa, XXa, XXIIa, XXIVa, XXVIa, and XXIXa-XXXa) are given in Table 2. The* H NMR spectra enabled the ...