Helvetica chimica acta

Stereospecific synthesis of carbanucleotides designed for antisense methodology

XF Zhu, F Nydegger, A Gossauer

文献索引：Zhu, Xue-Feng; Nydegger, Freddy; Gossauer, Albert Helvetica Chimica Acta, 2004 , vol. 87, # 9 p. 2245 - 2265

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被引用次数: 8

摘要

Abstract A short stereospecific synthesis of the carbocyclic 2′-deoxynucleoside analogues 36 and 37 (Schemes 2 and 5) and 45 and 46 (Schemes 2 and 6) starting from optically active 8, 9, 10-trinorborn-5-en-2-one (1) is described. As two functional groups capable to react with each other are present in the same molecule of the synthetic carbanucleosides, the latter can form polymers similar to oligonucleotides.