Tetrahedron letters

New methodology for high throughput solution-phase synthesis: affinity purification by using crown ether and ammonium ion interaction

S Zhang, K Fukase, S Kusumoto

文献索引：Zhang, San-qi; Fukase, Koichi; Kusumoto, Shoichi Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7479 - 7483

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被引用次数: 26

摘要

A new method for affinity purification of synthetic compounds by using crown ether- ammonium ion interaction and its application to the synthesis of several peptides and heterocycles are described. The desired compounds possessing the crown ether (32-crown- 10) moiety were readily isolated from the reaction mixture by the following procedure. After each reaction cycle, the reaction mixture was applied to the aminomethylated polystyrene ...