Direct cleavage of peptides from a solid support into aqueous buffer. Application in simultaneous multiple peptide synthesis

…, RM Valerio, RA Campbell, HM Geysen

文献索引：Bray, Andrew M.; Maeji, N. Joe; Valerio, Robert M.; Campbell, Rhonda A.; Geysen, H. Mario Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6659 - 6666

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被引用次数: 71

摘要

A method of simultaneous multiple peptide synthesis which integrates synthesis, side-chain deprotection, cleavage, and purification so as to afford peptide solutions suitable for immediate biological testing is described. The approach utilizes a novel diketopiperazine- forming cleavable linker 1. Upon side-chain deprotection, 1 gives 2, which is stable to a protocol designed to remove contaminants from the support-bound peptide prior to ...