Development of an Optimized Process for the Preparation of 1-Benzylazetidin-3-ol: An Industrially Important Intermediate for Substituted Azetidine

…, E Mahesh Reddy, C Kameswararao…

文献索引：Krishna Reddy; Udaykiran; Chintamani; Mahesh Reddy; Kameswararao, Ch.; Madhusudhan Organic Process Research and Development, 2011 , vol. 15, # 2 p. 462 - 466

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被引用次数: 4

摘要

A thoroughly optimized and robust process for the synthesis of 1-benzylazetidin-3-ol has been emphasized. 1-Benzylazetidin-3-ol has been utilized as a starting material in the commercial synthesis of azetidin-3-ol hydrochloride. Synthesis of azetidin-3-ol hydrochloride involves the usage of very low cost and commercially available starting material (benzylamine) and with reduced formation of di (3-chloro-2-hydroxypropyl) benzylamine ...