Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors

F Zhao, Z Lin, F Wang, W Zhao, X Dong

文献索引：Zhao, Feng; Lin, Zhaohu; Wang, Feng; Zhao, Weili; Dong, Xiaochun Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5385 - 5388

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被引用次数: 10

摘要

Abstract We report herein the design and synthesis of novel azaspirocycle or azetidine substituted 4-anilinoquinazoline derivatives. The EGFR inhibitory activities and in vitro antitumor potency of these newly synthesized compounds against two lung cancer cell lines HCC827 and A549 were evaluated. Most of the target compounds possess good inhibitory potency. In particular, compounds 21g with 2-oxa-6-azaspiro [3.4] octane substituent was ...